PTGS2 and neuroblastoma: Velagapudi et al., by evaluation of the impact of freeze-dried pomegranate juice (PWE 50–200 μg/ml) on IL-1β-stimulated human neuroblastoma SK-N-SH cells, announced that PWE strongly reduced the production of prostaglandin E2(PGE2), an inhibitor of kappa B (IκB) and IκB kinase (IKK) phosphorylation, and beta-secretase 1 (BACE-1), cyclooxygenase-2 (COX-2), and beta-amyloid (Aβ) expression (Velagapudi et al., 2016).