Moreover, blockade of either peripheral or brain irisin, using anti-FNDC5/irisin neutralizing antibody, prevented the neuroprotective effects of the physical exercise on memory and synaptic plasticity, indicating that irisin mediates the neuroprotective actions of exercise in the brain of AD mouse models (Lourenco et al., 2019). The gene discussed is FNDC5; the disease is Alzheimer disease.