In WHO grades II, III, and IV gliomas, RBPS was positively correlated with CD274, CD276, CD80, CD86, CTLA4, FAS, and PDCD1LG2. Finally, to identify potential drugs that targeted RBPS, the potential drugs related to the expression of these six RBP genes were queried in the database, and a correlation analysis was performed. The gene discussed is PDCD1LG2; the disease is central nervous system cancer.