In this study, RBPS was negatively correlated with dendritic cell infiltration and positively correlated with CD8+ T cells, which implied that, in gliomas with a high RBPS risk, a complete CD8+ T cell reactivation for immunotherapy may be difficult due to the lack of dendritic cells, thus making the anti-tumor effects difficult to be achieved. The gene discussed is CD8A; the disease is central nervous system cancer.