In addition, the expressions of protective genes (POLR2F, DYNC1H1, and SMAD9) for glioma in the GSE72951 dataset increased, while those of the risk genes (TRIM21, BRCA1, and ERI1) decreased so that the risk scores of patients in GSE72951 were the lowest among the three groups, but the median overall survival time was the shortest among the three datasets. Here, SMAD9 is linked to central nervous system cancer.