In all WHO grade II-IV gliomas, DNAss was positively correlated with the RBPS score, ERI1, BRCA1, and TRIM21, while negatively correlated with POLR2F, DYNC1H1, and SMAD9 [Spearman correlation, Benjamini-Hochberg (BH)-adjusted p < 0.05]. The gene discussed is TRIM21; the disease is central nervous system cancer.