Researchers have noticed that GABARAPL1 can confer an affinity for several mutated proteins that form aggregates in neurodegenerative diseases, and the degradation of GABARAPL1 can induce these neurodegenerative diseases to progress, further suggesting the importance of GABARAPL1 in the prevention of neurodegenerative diseases (Simunovic et al., 2009; Le Grand et al., 2011). This evidence concerns the gene GABARAPL1 and neurodegenerative disease.