Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP3) is a death inducing mitochondrial protein that is a member of the Bcl-2 family without a functional BH3 domain, has been suggested affect Aβ-induced neuronal death in AD (Zhang et al., 2007). The gene discussed is BNIP3; the disease is Alzheimer disease.