SOD1 and diabetes mellitus: It is a flavonol compound with multiple biological activities, which can exert antioxidant effects by activating the NrF-2-ARE pathway or by promoting the expressions of antioxidant proteins (CAT and SOD) to improve the symptoms of several diseases, including neurodegenerative diseases, tumors, inflammatory diseases, obesity and diabetes (Wang et al., 2013; Kumar et al., 2016; Mukhopadhyay et al., 2018; Yarahmadi et al., 2018; Ebrahimpour et al., 2020; Abdou et al., 2022).