With the aging of population, CAVD, as the most prevalent valve disease, increasingly afflicts the elderly people without effective medical treatment to prevent or reverse its initiation and advancement [3].The aberrantly elevated expression of THBS2 has been viewed to be associated with several processes related to the progression of CAVD, including inflammation, ECM remodeling, and neovascularization [7]. The gene discussed is THBS2; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.