RUNX2 and congenital bilateral aplasia of vas deferens from CFTR mutation: More and more researchers are working to find suitable diagnostic and therapeutic targets for CAVD [13], for example, it has been reported that miR-125b and CCL4 appear to be involved in the progression of CAVD and may offer novel therapeutic and diagnostic strategies related to this disease [14]; besides, calcium signaling pathway genes RUNX2 and CACNA1C are associated with CAVD [15].