Furthermore, glioblastoma with TIC phenotype show upregulation of Notch1 signaling proteins NICD and Hes‐1, and knock-down of Notch1 in these cells diminishes their tumorsphere formation ability, self‐renewal, chemoresistance, and expression of OCT4, SOX2, and NANOG 82. The gene discussed is SOX2; the disease is glioblastoma.