In this study, CXCL11 signaling through CXCR3 led hepatocellular carcinoma cells to acquire and maintain properties like self-renewal, tumorigenicity, and chemoresistance via activation of the ERK1/2 pathway, and CXCL11 knock-down reduced tumorgenicity in a mouse xenograft model 115. The gene discussed is CXCL11; the disease is hepatocellular carcinoma.