KRAS and neoplasm: At the same time, some studies have indicated that the larger the copy number of KRAS gene mutation is, the higher the malignant degree of the tumor becomes, which plays an important role in the substitution of low-dose KRAS mutated tumor MYC proto-oncogene (MYC), YAP and nuclear factor of kappa light polypeptide gene enhancer in B cells 2 (NFKB2), and promotes the invasion and metastasis of the tumor 17.