Nie et al. 108 have treated patients with KRAS mutation-positive pancreatic cancer using Verteporfin in combination with a pan-Raf targeted inhibitor (LY3009120), and the results show that the combination significantly enhances the anti-tumor efficacy of LY3009120; Roberge et al.109 found in animal studies that compared to gemcitabine alone, Verteporfin in combination with gemcitabine improves survival in mice, which, however, is photosensitive and cytotoxic and has been proven exposed to relatively large side effects110, 111. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.