PTGS2 and neoplasm: By estimating the co-expression relationship of the prognostic and specific biomarkers of different tumor infiltration immune cells via the GEPIA database in Table 2, we determined that PER-1 expression was significantly correlated with NOS2 and PTGS2 (M1 macrophage), VSIG4 (M2 macrophage), and KIR3DL2 (natural killer cells); CRY2 expression was closely correlated with CD3D (T cell), IRF5 (M1 macrophages); NPAS2 expression was closely correlated with CD3D (T cells), CD86 (monocytes), IRF5 and NOS2 (M1 macrophages), and ITGAM (neutrophils).