ACSS2 and obesity due to melanocortin 4 receptor deficiency: Related studies have found that ACSS2 is located in the cytoplasm and nucleus of mammals, and which is the main subtype that catalyzes the production of acetyl coenzyme A from free acetic acid to synthesize fatty acids (43), and lacking ACSS2 significantly reduced body weight and reversed hepatic steatosis in a diet-induced obesity mice model, suggesting that ACSS2 may have a therapeutic role in the treatment of fatty liver.