TMIGD2 and infection: We screened key candidate genes from these pathways, including CCL20, CCL5, CXCL11, CXCL16, IL2RB, IL2RG, IL9R, CD5, CD3E, CD244, TMIGD2, LAT, LCK, and ACKR3. CC chemokines can activate specific chemokine receptors and cause inflammatory and non-inflammatory cells to migrate to sites of infection or damage, leading to a series of physiological and biochemical reactions.