JAK2 and Cognitive impairment: Hou et al. (2018) found resveratrol provides neuroprotection by activating the JAK2/STAT3/PI3K/AKT/mTOR pathways in stroke rat models. In addition, Chen et al. (2018) found that ginsenoside Rg1 alleviates cognitive impairment and neural senescent stem cells in D-galactose-induced mouse models by reducing oxidative stress and downregulating Akt/mTOR signaling.