Quercetin represses chemoresistance, survival, growth, migration, and proliferation of LC cells by perturbing the activities of p53, B-cell lymphoma-extra-large (Bcl-xL), Janus kinase (JAK)/STAT, β-catenin, casein kinase (CK) 2α, Notch1, hedgehog, cyclin, PI3K/Akt, protein kinase C (PKC), cyclooxygenase-2 (COX-2), Bax, specificity protein 1 (SP1), and mitogen-activated protein kinase (MEK)/ERK pathways [171–180]. The gene discussed is PRRT2; the disease is laryngotracheoesophageal cleft.