Intracranial KL protein decreased, and NF-κB pathway activation was increased in hippocampus and frontal cortex, and inflammatory indicators such as IL-1, TNF-α, and IL-6 in nephrectomized mice with cognitive impairment, suggesting that KL protein and NF-κB signaling pathway are negatively correlated [37]. This evidence concerns the gene KL and Cognitive impairment.