In addition to that, the PI3K/AKT pathway was found to be suppressed in the presence of miR-29b-1-5p or to be activated in the presence of RTN4 in LPS-induced ALI, while a further demonstration that this signaling pathway engages in the regulation of miR-29b and RTN4 in ALI is required. The gene discussed is AKT1; the disease is acute respiratory distress syndrome.