More importantly, ACTN4 overexpression could reverse the inhibition effect of sh-TP73-AS1 on NSCLC cell growth and migration, which indicated that ACTN4 is involved in the regulatory network of TP73-AS1/miR-125a-3p/ACTN4 and affecting NSCLC progression. Here, ACTN4 is linked to non-small cell lung carcinoma.