CD8A and neoplasm: Meanwhile, in situ inoculation of NRTUAs can rapidly recruit CD45+ leukocytes (a marker for hematopoietic tumors to detect the differentiation of blood lymphocytes) and CD8+ T cells to the tumor (Baird et al., 2013b), and then increase the expression of IFN-γ by CD8+ T cells (Sanders et al., 2015) and possibly NK cells (Figure 1) (Levy et al., 2011).