After subcutaneous inoculation of B16F10 melanoma cells and Lewis lung cancer cells in the right armpit of mice, the proportion of Treg cells (CD4+CD25+Foxp3+) is decreased, and which of NK cells increased significantly in the spleen of mice after inoculation with ESP, and the tumor tissue was significantly smaller than that of the control group (without ESP treatment group) (Jiao et al., 2011; Yu-Meng et al., 2019). The gene discussed is CD4; the disease is neoplasm.