IFNG and neoplasm: In response to T. gondii infection, innate immunity swiftly produces IL-12, which can amplify the response of T cells and NK cells by expressing IFN-γ, promote the differentiation of M1 macrophages, and inhibit angiogenesis, showing a superior anti-tumor response (Gazzinelli et al., 1993; Airoldi et al., 2007; Biswas and Mantovani, 2010).