Significantly, even with the pre-inoculation of profilin or STAg, IFN-γ-/- mice also failed to restrain the growth of the pancreatic tumors, indicating that both IFN-γ and DCs are indispensable for the treatment of pancreatic cancer (Payne et al., 2021). The gene discussed is IFNG; the disease is pancreatic neoplasm.