Compared with para-cancerous tissues, hnRNPA2B1 was highly expressed in NSCLC and could bind to ERK/p53/HDM2 signaling pathway, suggesting that hnRNPA2B1 may be involved in NSCLC pathogenesis (Kim et al., 2021; Jin et al., 2022). This evidence concerns the gene MDM2 and non-small cell lung carcinoma.