It has been shown that knockdown of METTL3 can inhibit the proliferation, drug resistance and metastasis of NSCLC cells and induce apoptosis, as well as alter the phosphorylation of PI3K/AKT signaling pathway members, thereby exerting oncogenic effects (Jin et al., 2021; Zhang et al., 2021). Here, METTL3 is linked to non-small cell lung carcinoma.