Our results also suggest that the UPEC CFT073 Fim ON mutant that expresses high levels of mannose – binding, type 1 fimbria; and type 1 fimbria -expressing Salmonella Typhimurium [one of the bacterial species most studied as a bioengineered bacterium for cancer therapy (Chen et al., 2022)], have potential for use as vehicles for specific targeting of bladder cancer. Here, ZMYM2 is linked to cancer.