PTGS2 and periodontitis: (Campi et al., 2016) have found that after 7 days of the induction of periodontitis, the vascular response of adult rat aorta was impaired in terms of norepinephrine-induced contraction and acetylcholine-dependent relaxation, and the endothelium-derived NO and cyclooxygenase 2 (COX-2) were involved in the process (Zhou et al., 2019; De Oliveira et al., 2021).