Potential biomarkers linking periodontitis with endothelial dysfunction, including C-reactive protein (CRP), interleukin (IL)-1, ICAM-1, E-selectin, vWF, plasminogen activator inhibitor type-1 (PAT-1), and plasminogen, have been found to be decreased after periodontal treatment (Tonetti et al., 2007; Li et al., 2011b; D'Aiuto et al., 2013; Hansen and Holmstrup, 2022). This evidence concerns the gene CRP and periodontitis.