CD40LG and malaria: Moreover, IgM has been suggested to contribute to human parasite clearance (Boudin et al., 1993; Bolad et al., 2005; Arama et al., 2015; Boyle et al., 2019; Hopp et al., 2021; Kurtovic et al., 2021), which may highlight an underestimated role of IgM in protecting against the frequent malaria re-infections in endemic regions (Krishnamurty et al., 2016).