It was found that, in a T cell transfer colitis model, the transfer of Foxp3+Tregs could inhibit the inflammatory response of the colon, induce the transformation of IgA+ plasmacytes in the lamina propria of the intestinal mucosa, promote the production of SIgA, and maintain the diversity of gut microbiota (Kawamoto et al., 2014; Wang et al., 2015), while depletion of Foxp3+Tregs decreased the intestinal IgA responses, resulting in a decrease in firmicutes and an increase in proteobacteria and aggravating colitis (Cong et al., 2009; Kawamoto et al., 2014). The gene discussed is FOXP3; the disease is colitis.