The common TRAEs included neutropenia 50.8% (31/61), abdominal pain 45.9% (28/61), ALT increase 39.3% (24/61), thrombocytopenia 36.1% (22/61), hypertension 36.1% (22/61), AST increase 32.8% (20/61), hand foot syndrome 26.2% (16/61), rash 23.0% (14/61), and hypothyroidism 18.0% (11/61). The gene discussed is GPT; the disease is hypothyroidism.