Aβ can competitively bind to insulin receptors and stimulate insulin resistance, and Aβ has been shown to inhibit autophosphorylation of the insulin receptor and reduce insulin receptor levels and activity (Ling et al., 2002; Xie et al., 2002; Zhao et al., 2008; De Felice et al., 2009; Bomfim et al., 2012). This evidence concerns the gene INSR and Insulin resistance.