However, no Aβ deposits were found in the islets of AD mice, and no Aβ deposits were found in the islets of T2DM mice, indicating that the Aβ deposits in the pancreas were not generated by pancreatic APP, but possibly from Aβ in the blood circulation, and the accumulation of Aβ in the pancreas was the result of cross-inoculation with IAPP (Wijesekara et al., 2017). This evidence concerns the gene APP and Alzheimer disease.