BBB damage may attenuate the expression of LRP1 and cause clearance of Aβ, and may also increase the expression of RAGE, increase the Aβ transported into the brain, and promote the progression of AD (Jaya Prasanthi et al., 2008; Zlokovic, 2011); Fourth, the blood cerebrospinal fluid barrier transport of Aβ. The gene discussed is LRP1; the disease is Alzheimer disease.