LRP1 and Alzheimer disease: In the case of AD, the expression of LRP1 and RAGE is completely opposite to that in the case of non-AD, which may be the compensation of the body for b BBB transport disorders (Johanson et al., 2008; Wraith and Nicholson, 2012; Gonzalez-Marrero et al., 2015); Fifth, astrocyte-mediated intracellular lymphatic system (ISF bulk flow).