To this end, we sought the prevalence of SNPs in the 3′-UTR of the ACHE gene or single and dual co-inherited SNPs in coding or non-coding regions of BChE in AD (n = 69), PD (n = 28), and CTRL (n = 54) brains as compared to the genetic dataset of the GTEx cohort (n = 651). This evidence concerns the gene ACHE and Alzheimer disease.