Rather, both our AD and PD samples and the larger GTEx cohort displayed modified incidence of SNPs in both the coding and non-coding sequences of the BCHE gene and co-inheritance of the BCHE SNPs in the 5′-UTR (rs1126680) and intron 2 (rs55781031), which show opposite trends of AD- and PD-related change to that of the BChE-K variant (rs1803274). Here, BCHE is linked to Alzheimer disease.