For example, AChE-S plays an important role in AD (Jing et al., 2013) and in inflammatory states (Vaknine and Soreq, 2020), while AChE-R mRNA and AChE-Next levels are higher in stress-related or neurodegenerative disorders (Meshorer and Soreq, 2006). Here, ACHE is linked to Alzheimer disease.