A dysregulation in the levels of PSD95 and GABA reportedly contributes to pain and memory impairment (Perez-Sanchez et al., 2017; Coley and Gao, 2019; Kumari et al., 2020), while reduced PSD95 levels are predictive of cognitive deficits (Whitfield et al., 2014). The gene discussed is DLG4; the disease is Cognitive impairment.