It was previously established that AR activation directly controlled the transcription of Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) and upregulated its downstream chemokines, such as CCL-3, CCL-4, and CCL-13, which nonspecifically bind to chemokine receptors to promote the exfoliation of PCa cells. Here, TREM1 is linked to posterior cortical atrophy.