In this context, we analyzed changes in estradiol, progesterone, testosterone, FSH, LH, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) levels, and free androgen index (FAI) after NAC treatment in pre- and postmenopausal women diagnosed with invasive breast cancer. Here, SHBG is linked to invasive breast carcinoma.