These signals include, but not limited to, hypoxia-inducible factor 1 alpha (HIF1a), matrix metalloproteinase (MMPs), Casein Kinase II, Notch1, and Annexin A2 as well as growth factors like transforming growth factor B (TGF-B), which augment the migratory capability of the tumor recipient cells [76]. Here, HIF1A is linked to neoplasm.