In T2D, abnormal regulation of enzymes in the gene promoter region could alter gene expressions, and differentially expressed genes such as SET domain-containing lysine methyltransferase 7 (SET7) and suppressor of variegation 3–9 homolog 1 (SUV39h1) can affect inflammation-related pathways that lead to vascular injury. Here, SETD7 is linked to type 2 diabetes mellitus.