SMOC2 and Oligodontia: Interestingly, a patient with a loss-of-function mutation of SPARC related modular calcium binding 2 (SMOC2) - a secreted matricellular protein - was found to have dental and skeletal abnormalities, including oligodontia, microdontia, tooth root anomalies, alveolar bone hypoplasia, and skeletal deformities (Morkmued et al., 2020).