Elevated levels of NLRP3, caspase-1 and IL-1β protein expression and IL-1β and IL-18 transcription were identified in l-arginine-induced severe acute pancreatitis (SAP) (Liu et al., 2021), cisplatin (Li et al., 2018)and contrast agent related AKI (Xu et al., 2020)mouse models. The gene discussed is IL1B; the disease is acute pancreatitis.