One study reported reduced BMI, Ferriman-Gallway score, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores, while PCOS health-related quality of life questionnaire scores, serum sex hormone binding globulin (SHBG) levels and β -endorphin levels were elevated after acupuncture intervention in PCOS patients. The gene discussed is SHBG; the disease is major depressive disorder.