Explicitly, GLP-1 analogs were shown to induce PI3K/Akt and cAMP/PKA/CREB-signaling, resulting in a PI3K- and PKA-, but not ERK-, dependent and dose-related improvement in the viability and proliferation of SH-SY5Y neuroblastoma cells (Qin et al., 2008; Li et al., 2010c,2015). This evidence concerns the gene GLP1R and neuroblastoma.