GSK3B and Alzheimer disease: Indeed, GLP-1R agonists are potent stimulators of the neuroprotective modulator Akt that directly suppresses the abnormally increased GSK-3β activity in the brain of AD animal models (Cai et al., 2014; Qi et al., 2016; Cao et al., 2018; Wang et al., 2018; Zhou et al., 2019; Jantrapirom et al., 2020).