PPARGC1A and Alzheimer disease: For instance, the decreased expression of PGC-1α has been detected in the SNpc of PD patients (Jiang et al., 2016), while AD patients displayed diminished CytC oxidase/complex IV levels, whose expression is under control of PGC-1α (Xu et al., 2014; Yang et al., 2017), in their post-mortem brain tissue and isolated platelets (Parker et al., 1990; Cardoso et al., 2004).