MAPK8 and Alzheimer disease: On the other hand, studies in various disease models indicate that JNK is selectively stimulated by Aβ as well as proinflammatory cytokine exposure, but not Tau, in neurons in vivo and post-mortem hippocampal brain tissue of AD patients (Ma et al., 2009; Bomfim et al., 2012; Killick et al., 2014; Ojala and Sutinen, 2017).