Albeit increased GAPDH activity was reported in a small-scale post-mortem study (Soucek et al., 2003), substantially decreased GAPDH activity and elevated quantities of ROS-inactivated and S-glutathionylated GAPDH were detected in the temporal cortex, inferior parietal lobule or isolated skin fibroblasts of individuals with AD (Kish et al., 1998; Mazzola and Sirover, 2001; Newman et al., 2007). This evidence concerns the gene GAPDH and Alzheimer disease.