Both AD patients and 3 × Tg AD mice displayed early peripheral glucose intolerance that was followed by attenuated PI3K/Akt-signaling, glycolytic flux, neuronal GLUT3 levels (but not astroglia GLUT1) and GLUT3 translocation to the plasma membrane as well as elevated glucose levels in the brain, suggesting a link between peripheral and cerebral insulin resistance (An et al., 2018; Griffith et al., 2019). Here, AKT1 is linked to Alzheimer disease.