The cAMP/PKA/CREB pathway was shown to be impaired in the prefrontal cortex or hippocampus of AD patients (Yamamoto-Sasaki et al., 1999; Liang et al., 2007; Bartolotti et al., 2016), while the Aβ/Ca2+/calpain-mediated degradation of CREB, oxidative stress and astrogliosis reduce CREB levels, lead to CREB truncation and, as such, decrease the expression of GLUT3 during AD (Puzzo et al., 2005; Pugazhenthi et al., 2011; Jin et al., 2013). The gene discussed is CREB1; the disease is Alzheimer disease.