Based on the association of other protocadherins with epilepsy, such as Pcdh19 (Dibbens et al., 2008; also see Hoshina et al., 2021) and Pcdh7 (Lal et al., 2015), authors of the partial Pcdh11x duplication study hypothesized that the Pcdh11x mutation may be relevant for the seizures of this patient (Linhares et al., 2016). Here, PCDH11X is linked to epilepsy.