Conversely, reductions in CB1R have been detected in areas of microglial activation in brains of both people with AD and AD-relevant rodent models (Ramírez et al., 2005), and decreased levels of CB1R and AEA have also been found in Aβ42-treated rats (Esposito et al., 2007a). The gene discussed is CNR1; the disease is Alzheimer disease.