APP and Alzheimer disease: Chronic CB2R agonism also resulted in cognitive improvement and reduced microglial reactivity in APPSwe/PS1ΔE9 mice (B6; C3-Tg[APPswe,PSEN1dE9]85Dbo/Mmjax or APP/PS1 mice; a double transgenic mouse model of AD with disease-relevant mutations in amyloid precursor protein [APP] and presenilin 1 [PS1]).