The infiltrate of these cells leads to the formation of a capillary plug with the accumulation of neutrophils, monocytes, platelets, and red cells, in which neutrophils and monocytes release proinflammatory chemokines and cytokines, which promotes an exacerbated immune response that results in alterations such as ATN and cell apoptosis and culminates in acute kidney injury in these patients [75, 90, 93]. Here, TYR is linked to acute kidney injury.