Dysregulation of matrix metalloproteinase (MMP)‐2 and MMP‐9 has been observed with obesity, and contributes to the development of cardiovascular disease (Bäck et al., 2010; Jaoude & Koh, 2016; van Linthout et al., 2008). This evidence concerns the gene MMP9 and obesity due to melanocortin 4 receptor deficiency.