It would also be interesting to investigate if endocrine system, specifically estrogen, plays a role in the preservation of cardiac function in ATM‐deficient WD‐fed female mice as postmenopausal women are more susceptible to developing obesity and metabolic complications versus premenopausal women (Curtis, 2009; Mauvais‐Jarvis et al., 2017). Here, ATM is linked to obesity due to melanocortin 4 receptor deficiency.