Ang II enhances proximal tubular sodium reabsorption, an effect that is augmented in tubules from fructose‐fed rats (Cabral et al., 2014; Gonzalez‐Vicente et al., 2018; Gonzalez‐Vicente, Cabral, et al., 2019; Yang et al., 2020) and is an independent determinant of hypertension in response to salt intake (Chiolero et al., 2000). Here, AGT is linked to hypertensive disorder.