Not only is aortic stiffness a known risk factor of AAA growth (Boczar et al., 2021), but adverse aortic connective tissue remodeling in response to AAA is a known contributor to aortic wall stiffening because of its association to inflammation (Wales et al., 2014), elastin degradation (Kavazos et al., 2015), and collagen restructuring (Jones et al., 2020). This evidence concerns the gene ELN and triple-A syndrome.