First, we found that miR‐486 expression was downregulated significantly in the infarct zone and border zone 8 weeks after MI, accompanied by upregulation of SRSF3 (Figure 5A, B), indicating the involvement of miR‐486 and SRSF3 in the pathophysiology of post‐MI myocardium. This evidence concerns the gene SRSF3 and myocardial infarction.