SRSF3 and myocardial infarction: In addition, our findings showing that miR‐486 expression is downregulated and SRSF3 expression is upregulated in ischaemic myocardium, especially in the infarct zone, combined with the above novel mechanism, strongly suggest that the miR‐486/SRSF3/p21 pathway, which mediates senescence of CMFs, is a potential therapeutic target to improve the fibrotic activity and pathological fibrosis and remodelling seen in ischaemic myocardium, such as MI, and to benefit regeneration.