Previous studies reported that IL‐6 activates the JAK/STAT signaling pathway (Heinrich et al., 1998; Kaur et al., 2020; Mascareno et al., 2001; Schindler & Strehlow, 1999) which serves as a potential target for early intervention in IR‐induced acute renal failure (Yang et al., 2008). Here, IL6 is linked to acute kidney injury.