Several studies indicated to the role of JAK/STAT signaling pathway in the renal corpuscles in other renal disease models (via STAT3), such as in experimental nephrotic syndrome, unilateral ureteral obstruction (Li et al., 2007; Pang et al., 2010), and Alport syndrome (Yokota et al., 2018). Here, SOAT1 is linked to nephrotic syndrome.