APC mutation occurs early in premalignant (benign) lesions of the intestine, such as small polyps90, and APCmin (multiple intestinal neoplasia) mice carrying a dominant mutation in APC are predisposed to develop multiple intestinal adenomas91,92, similar to mutations causing familial adenomatous polyposis (FAP) in humans. The gene discussed is APC; the disease is Familial adenomatous polyposis.