ATP7B and dyslexia: Of note, a frameshift variant in ATP7B of uncertain significance was also identified in our previous CAS cohort [5]; in the present cohort, the identified variant (proband 49) is shared with their father; however the father has a history of self-reported but undiagnosed dyslexia without CAS, and the mother has a brief history of speech therapy as a child but also without a CAS diagnosis, so the variant does not fully segregate with CAS or speech affected status.