EGFR and colorectal carcinoma: Furthermore, we also observed significant mutually exclusivity between EGFR amplification and ARID1A mutations in lung (FDR < 0.1; Fig. 4b, top) and a tendency for mutually exclusivity between ARID1A mutations and EGFR amplification (0.92%) in CRC (FDR < 0.1; Fig. 4b, bottom).