Western blots were used to validate the cell transfection efficiency and the results are presented in Fig. S7A. Lentiviral expression vectors (pLVX-IRES-Neo-3xFlag, pLVX-MPZ-IRES-Neo-3xFlag, pLVX-SCARA3-IRES-Neo-3xFlag, pLVX-MPP2-IRES-Neo-3xFlag or pLVX-PBXIP1-IRES-Neo-3xFlag) were used to over-express MPZ (vector and MPZ), SCARA3 (vector and SCARA3), MPP2 (vector and MPP2) or PBXIP1 (vector and PBXIP1) in the CRC cell line SW480, and SW480 cells transfected with vector were considered the control. Here, MPP2 is linked to colorectal carcinoma.