Lung cancer-related studies show that SIRT7 is overexpressed in NSCLC and SIRT7 can promote human NSCLC cell growth and metastasis via regulating G1-to-S-phase transition, EMT, and activation of Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling [94, 95]. This evidence concerns the gene MAPK3 and lung cancer.