AKT1 and non-small cell lung carcinoma: Lung cancer-related studies show that SIRT7 is overexpressed in NSCLC and SIRT7 can promote human NSCLC cell growth and metastasis via regulating G1-to-S-phase transition, EMT, and activation of Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling [94, 95].