As for asthma, Fang et al. found that the expression of SIRT7 was increased in airway smooth muscle (ASM) cells treated with transforming growth factor-beta 1 (TGF-β1), and SIRT7 participated in regulating TGF-β1-induced ASM cell proliferation and migration by regulating TGF-β receptor I (TβRI), suggesting the important role of SIRT7 in asthmatic airway remodeling [97]. The gene discussed is TGFB1; the disease is asthma.