Huang et al. [9] found that the micropeptide HOXB-AS3 encoded by lncRNA HOXB-AS3 inhibits the growth of colon cancer (CRC), and Polycarpou-Schwarz et al. [10] discovered the micropeptide CASIMO1 (cancer-associated small integral membrane open reading frame 1), which has an oncogenic effect. Here, SMIM22 is linked to colonic neoplasm.