EGFR and renal carcinoma: After knocking down these genes by RNAi interference technology (Fig. 5C), combined with CCK8 cell proliferation assay and transwell cell migration assay screening (Fig. 5D, E), it was found that knocked down the epidermal growth factor receptor (EGFR) and its ligand epiregulin (EREG) have the most significant inhibitory effect on the function of renal cancer cells.