Another potentially beneficial effect of Ang II related to reducing catecholamine exposure is the finding that NE was associated with increased MVO2, as assessed using the “Triple product.” This observation suggests higher oxygen consumption with NE administration, with no beneficial effect on tissue perfusion, and may have important clinical implications, especially in patients with ischemic cardiomyopathy or other causes of impaired myocardial perfusion. This evidence concerns the gene AGT and ischemic cardiomyopathy.