g., nelarabine, bendamustine, asparaginase, ifosfamide, imatinib et al.). A previous study [79] has reported that the expression of CD69 might predict the response to bendamostine, its regulation by ibrutinib or idlisib could enhance the cytotoxic effects of chronic lymphocytic leukemia. This evidence concerns the gene ASPG and B-cell chronic lymphocytic leukemia.