Among them, the three pathways that up-regulated genes are mainly involved in are cytokine-cytokine receptor interaction, viral protein interaction with cytokines and cytokine receptors, and chemokine signaling pathway, while the three pathways that down-regulated genes are mainly involved in are TNF signaling pathway, Yersinia infection, and JAK-STAT signaling pathway. The gene discussed is TNF; the disease is Yersinia infectious disease.