PCDH7 could promote the malignant transformation of bronchial epithelial cells carrying KRAS gene mutation, while knockdown of PCDH7 inhibited the growth and metastasis of lung cancer cells with a mutated KRAS gene, suggesting that PCDH7 and KRAS had a synergistic cancer-promoting effect [71, 72]. The gene discussed is KRAS; the disease is lung carcinoma.